胚胎技術(shù)重大突破未來(lái)也可人工制造？

由雕龍文庫(kù) 分享時(shí)間：2024-03-31 14:12:28 收藏本文

近日，《科學(xué)》雜志在線報(bào)道稱(chēng)，劍橋大學(xué)的科學(xué)家們通過(guò)使用兩種干細(xì)胞以及一個(gè)三維支架，成功地創(chuàng)造出了一個(gè)能夠自行組裝的結(jié)構(gòu)，其發(fā)育和構(gòu)造非常接近自然的小鼠胚胎。科學(xué)家的研究目的并非制造怪胎，而是為了探究人類(lèi)的早期發(fā)育、妊娠失敗和遺傳缺陷。

Artificial human life could soon be grown from scratch in the lab, after scientists successfully created a mammal embryo using only stem cells.

在科學(xué)家成功利用干細(xì)胞培育出哺乳動(dòng)物胚胎后，人工制造的人類(lèi)胚胎很快也將能夠被培育出來(lái)。

Cambridge University mixed two kinds of mouse stem cells and placed them on a 3D scaffold. After four days of growth in a tank of chemicals designed to mimic conditions inside the womb, the cells formed the structure of a living mouse embryo.

劍橋大學(xué)研究人員將兩種小鼠干細(xì)胞混合并放置在一個(gè)三維支架上，在模仿子宮內(nèi)條件的有化學(xué)物質(zhì)的容器內(nèi)長(zhǎng)了四天，細(xì)胞形成了存活的小鼠胚胎結(jié)構(gòu)。

The breakthrough has been described as a ‘masterpiece’ in bioengineering, which could eventually allow scientists to grow artificial human embryos in the lab without the need for a sperm or an egg.

這一突破被稱(chēng)為生物工程中的“杰作”，科學(xué)家們最終將可以在不需要精子或卵子的前提下，在實(shí)驗(yàn)室里培育出人工胚胎。

Growing embryos would help researchers to study the very early stages of human life so they could understand why so many pregnancies fail, but is likely to prove controversial and raise ethical questions about what constitutes human life.

培育人工胚胎將有助于研究人員研究人類(lèi)活動(dòng)最早的階段，去探索很多人懷孕失敗的原因，但此舉有可能引發(fā)爭(zhēng)議，并提出什么構(gòu)成了人類(lèi)生命的倫理問(wèn)題。

Currently scientists can carry out experiments on leftover embryos from IVF treatments, but they are in short supply and must be destroyed after 14 days. Scientists say that being able to create unlimited numbers of artificial embryos in the lab could speed up research while potentially removing some of the ethical boundaries.

目前科學(xué)家能使用試管受精中的剩余胚胎繼續(xù)實(shí)驗(yàn)，但供不應(yīng)求，并在14天后就必須被摧毀。科學(xué)家們說(shuō)，在實(shí)驗(yàn)室中創(chuàng)造無(wú)限數(shù)量的人工胚胎可加快研究，但與此同時(shí)可能跨越了一些倫理界限。

“We think that it will be possible to mimic a lot of the developmental events occurring before 14 days using human stem cells," said Professor Magdalena Zernicka-Goetz from the Department of Physiology, Development and Neuroscience at Cambridge, who led the research.

“我們認(rèn)為，可以使用人類(lèi)干細(xì)胞來(lái)模仿14天內(nèi)的發(fā)展變化。”研究帶頭人、劍橋大學(xué)生理發(fā)展和神經(jīng)科學(xué)系的Magdalena Zernicka Goetz教授說(shuō)。

"We are very optimistic that this will allow us to study key events of this critical stage of human development without actually having to work on (IVF) embryos. Knowing how development normally occurs will allow us to understand why it so often goes wrong."

“這個(gè)研究將使我們不需要研究 Britain is currently leading the world in fertility research, and last year a group at the Francis Crick Institute was granted permission to genetically modify human embryos, the first time in the world such a procedure had been approved by regulators.

英國(guó)目前的生育研究世界領(lǐng)先。2024年，弗蘭西斯克里克學(xué)院一個(gè)研究小組被批準(zhǔn)進(jìn)行基因改造的人類(lèi)胚胎繁殖實(shí)驗(yàn)，這是世界上首次獲得監(jiān)管機(jī)構(gòu)批準(zhǔn)的實(shí)驗(yàn)。

However such work raises important ethical questions about the sanctity of human life and whether it should be manipulated or created in the lab at all.

然而這樣的研究引發(fā)了關(guān)于人類(lèi)生命的尊嚴(yán)和人類(lèi)生命是否應(yīng)該被操縱或在實(shí)驗(yàn)室里創(chuàng)造的重要倫理問(wèn)題。